Enantioselective kinetic disposition of fenoprofen in rats with experimental diabetes or adjuvant-induced arthritis.

Abstract

This study was aimed to investigate the influence of diabetes or arthritis on the enantioselective metabolism and kinetic disposition of fenoprofen in rats with streptozotocin-induced diabetes or Mycobacteriumtuberculosis adjuvant-induced arthritis. Animals received i.v. 10 mg/kg racemic fenoprofen and blood samples were collected up to 24 h thereafter, with 5 animals studied at each time point. Plasma concentrations of the fenoprofen enantiomers were determined by HPLC. Diabetic and arthritic animals showed significant differences when compared with respective controls for the following pharmacokinetic variables of the (+)-(S)-fenoprofen eutomer: area under the plasma concentration time curve, total clearance and volume of distribution. The results indicate that experimental diabetes and adjuvant-induced arthritis influence the fenoprofen enantioselective metabolism.

• Authors: Josiane Cristófani Poggi, Giuliano Rodrigo Barissa, Eduardo Antônio Donadi, Vera Lucia Lanchote, Marina Lemos dos Reis
• Journal: Pharmacology (Pharmacology) Vol. 72 Issue 2 Pg. 85-91 (Oct 2004) ISSN: 0031-7012 [Print] Switzerland
• PMID: 15331913 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Cyclooxygenase Inhibitors
• Fenoprofen

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (blood, chemistry, pharmacokinetics)
• Area Under Curve
• Arthritis, Experimental (metabolism)
• Chromatography, High Pressure Liquid
• Cyclooxygenase Inhibitors (blood, chemistry, pharmacokinetics)
• Diabetes Mellitus, Experimental (metabolism)
• Fenoprofen (blood, chemistry, pharmacokinetics)
• Male
• Metabolic Clearance Rate
• Rats
• Rats, Wistar
• Stereoisomerism