Abstract | BACKGROUND & AIMS: METHODS: The efficacy of increasing doses of oral butyrate (from 50 to 100 mg/kg/day) was investigated through the daily evaluation of stool volume, bowel movements, fecal incontinence, serum, and stool electrolytes concentrations. The modifications in transepithelial intestinal ion transport elicited by butyrate were examined by rectal dialysis study. RESULTS: A butyrate dose of 100 mg/kg/day induced a normalization of stool pattern and of serum and fecal electrolytes concentration. The rectal dialysis study demonstrated a proabsorptive effect induced by butyrate on Na+, Cl-, and K+ intestinal transport. Butyrate therapy was well tolerated during the entire 12-month observation period, and the stool pattern and fecal and serum ion concentrations remained stable within the normal ranges. No clinical adverse events or episodes of dehydration requiring hospital care were observed. CONCLUSIONS:
Butyrate could be effective in treating congenital chloride diarrhea. It is easily administered, useful in preventing severe dehydration episodes, and may be a promising therapeutic approach for a long-term treatment in this rare and severe condition.
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Authors | Roberto Berni Canani, Gianluca Terrin, Pia Cirillo, Giuseppe Castaldo, Francesco Salvatore, Giuseppe Cardillo, Anna Coruzzo, Riccardo Troncone |
Journal | Gastroenterology
(Gastroenterology)
Vol. 127
Issue 2
Pg. 630-4
(Aug 2004)
ISSN: 0016-5085 [Print] United States |
PMID | 15300594
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Butyrates
(administration & dosage)
- Child
- Chlorides
(metabolism)
- Dehydration
(prevention & control)
- Diarrhea
(congenital, drug therapy, metabolism)
- Feces
- Humans
- Male
- Severity of Illness Index
- Water-Electrolyte Balance
(drug effects)
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