Erectile function after brachytherapy with external beam radiation for prostate cancer.

Abstract

The effect of therapeutic modalities on sexual potency is an important consideration for patients choosing a treatment for prostate cancer. We assessed erectile function after iridium-192 (1r-192) high-dose rate (HDR) brachytherapy with external beam radiation therapy (EBRT), and examined the efficacy of sildenafil after this treatment. Forty-two prostate cancer patients (T1c to T3bN0M0) were treated with 22Gy HDR brachytherapy with 36.8Gy EBRT without neoadjuvant hormone therapy. Erectile function was assessed using a 5-item version of the International Index of Erectile Function questionnaire (IIEF-5), pre, 3 and 12 months after treatment, Potency was defined as an IIEF-5 score > or = 11. Ten patients with potency before HDR brachytherapy with EBRT with or without neoadjuvant hormone therapy requested Sildenafil 3 months after treatment. The mean IIEF-5 score of all patients was 10.5 +/- 8.5, 4.5 +/- 5.3 (p < 0.001), and 3.8 +/- 4.7 (p < 0.001), pre, 3 and 12 months after treatment, respectively. Seventeen (40.4%) patients were potent before treatment. The mean IIEF-5 score of those patients was 15.8 +/- 3.2, 9.6 +/- 5.1 (p = 0.04), and 11.3 +/- 6.1 (p = 0.06), pre, 3 and 12 months after treatment, respectively. Ten of 17 (58.8%) patients maintained their potency 12 months after treatment. In 10 patients with potency before treatment who were treated with sildenafil, the mean IIEF-5 score increased from 6.2 +/- 3.5 at 3 months to 13.6 +/- 5.1 (p < 0.001) at 12 months after treatment. Eight of 10 (80%) patients treated with sildenafil had recovered 12 months after treatment. HDR brachytherapy with EBRT can be performed with favorable results for maintaining potency.

• Authors: H Fujioka, T Ishimura, Y Sakai, T Fujii, Y Jo, A Takenaka, M Fujisawa
• Journal: Archives of andrology (Arch Androl) 2004 Jul-Aug Vol. 50 Issue 4 Pg. 295-301 ISSN: 0148-5016 [Print] England
• PMID: 15277008 (Publication Type: Journal Article)

Chemical References

• Iridium Radioisotopes
• Prostate-Specific Antigen

Topics

• Adult
• Aged
• Brachytherapy (adverse effects, methods)
• Dose-Response Relationship, Radiation
• Erectile Dysfunction (etiology)
• Follow-Up Studies
• Humans
• Iridium Radioisotopes
• Male
• Middle Aged
• Penile Erection (radiation effects)
• Prostate-Specific Antigen (blood)
• Prostatic Neoplasms (radiotherapy)
• Surveys and Questionnaires
• Time Factors