Single-dose cefixime versus single-dose ceftriaxone in the treatment of antimicrobial-resistant Neisseria gonorrhoeae infection.

Abstract

Sexually transmitted diseases (STDs) have a significant adverse effect on reproductive and child health worldwide. The control of STDs such as gonorrhea is therefore an absolute priority. Cefixime, an oral third-generation cephalosporin with in vitro activity similar to that of ceftriaxone, may be an effective candidate for the treatment of gonorrhea. The efficacy of a single oral 400-mg dose of cefixime was compared with that of a single intramuscular 250-mg dose of ceftriaxone for the treatment of Neisseria gonorrhoeae urethritis in 190 men and cervicitis in 46 women in Nairobi, Kenya. A bacteriologic cure was recorded in 100% of 63 evaluatable patients treated with ceftriaxone and 118 (98%) of 121 evaluatable patients treated with cefixime. Cefixime, as a single oral dose, is an effective alternative for the treatment of uncomplicated gonococcal urethritis in men and cervicitis in women.

• Authors: P J Plourde, M Tyndall, E Agoki, J Ombette, L A Slaney, L J D'Costa, J O Ndinya-Achola, F A Plummer
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 166 Issue 4 Pg. 919-22 (Oct 1992) ISSN: 0022-1899 [Print] United States
• PMID: 1527431 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Ceftriaxone
• Cefixime
• Cefotaxime

Topics

• Administration, Oral
• Adult
• Aged
• Anti-Bacterial Agents (administration & dosage)
• Cefixime
• Cefotaxime (administration & dosage, analogs & derivatives, therapeutic use)
• Ceftriaxone (administration & dosage, therapeutic use)
• Drug Evaluation
• Female
• Gonorrhea (drug therapy)
• Humans
• Injections, Intramuscular
• Male
• Microbial Sensitivity Tests
• Middle Aged
• Neisseria gonorrhoeae (drug effects)
• Urethritis (drug therapy, microbiology)
• Uterine Cervicitis (drug therapy, microbiology)