Treatment of nocturnal leg cramps. A crossover trial of quinine vs vitamin E.

Abstract

OBJECTIVE:

This study compared the efficacy and safety of quinine sulfate, vitamin E, and placebo in the treatment of nocturnal leg cramps.

DESIGN:

A random-order, double-blind, placebo-controlled crossover trial was performed.

SETTING:

The study was conducted at the Veterans Affairs Medical Center, White River Junction, Vt.

PARTICIPANTS:

Twenty-seven male veterans, aged 38 to 73 years, who experienced at least six leg cramps per month were recruited through the general medicine walk-in clinic or were referred from other clinics. Fifty-five subjects were contacted, 30 were enrolled consecutively, and 27 completed the study.

INTERVENTION:

Subjects received, in random order, quinine sulfate (200 mg at supper and 300 mg at bedtime), vitamin E (800 U at bedtime), or placebo for 4-week periods. These periods were separated by 4-week washout intervals.

OUTCOME MEASURES:

Patients reported cramp frequency, severity, and sleep disturbance caused by cramps.

RESULTS:

Compared with treatment with placebo, quinine reduced the frequency of cramps and sleep disturbance, but not the average cramp severity. Thirteen of 27 patients had at least a 50% reduction in the number of cramps while receiving quinine; the response was usually seen within 3 days. There was evidence of a mild increase in side effects while subjects received quinine. Vitamin E was not effective in reducing leg cramp frequency, severity, or sleep disturbance.

CONCLUSIONS:

Quinine sulfate, but not vitamin E, is superior to placebo in the treatment of nocturnal leg cramps.

• Authors: P S Connolly, E A Shirley, J H Wasson, D W Nierenberg
• Journal: Archives of internal medicine (Arch Intern Med) Vol. 152 Issue 9 Pg. 1877-80 (Sep 1992) ISSN: 0003-9926 [Print] United States
• PMID: 1520054 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Vitamin E
• Quinine

Topics

• Double-Blind Method
• Humans
• Leg
• Male
• Middle Aged
• Muscle Cramp (drug therapy)
• Quinine (therapeutic use)
• Sleep Wake Disorders (prevention & control)
• Vitamin E (therapeutic use)