[1, 2-Bis(2, 6-difluoro-3-hydroxyphenyl)ethylene-diamine]platinum(II) complexes, compounds for the endocrine therapy of breast cancer - mode of action II: contribution of drug inactivation, cellular drug uptake and sterical factors in the drug-target interaction to the antitumor activity.

Abstract

The marked activity of [meso-1, 2-bis(2, 6-difluoro-3-hydroxyphenyl)ethylenediamine]platinum(II) (meso-3-PtLL', L, L' = Cl(2) or L = OH(2), L' = OSO(3)) on the hormone-sensitive MXT-M-3, 2 breast cancer implanted in mice is most probably due to a mechanism based on the reduction of the endogenous estrogen level. Cytotoxic effects which are poorly pronounced in experiments on several breast cancer cell lines (e.g. MCF-7), do not significantly contribute to the anti-breast cancer activity of this compound. In contrast to this, the standard cisplatin and the structurally related comparison compound [meso-1, 2-bis(4-fluorophenyl)ethylenediamine]platinum(II) (meso-4-PtLL', L, L' = Cl(2) or L = OH(2), L' = OSO(3)) are strongly active in vivo as well as in vitro. Both effects entail programmed cell death, which is responsible for the inhibition of the tumor growth. The minor cytotoxicity of meso-3-PtLL' in breast cancer cell cultures is caused neither by an inappropriate rate of reaction with bionucleophiles (e.g. by a too fast inactivation by plasma proteins) nor solely by the observed poor absorption by the tumor cells resulting in an insufficient drug concentration at the DNA. Additionally, an impeded reaction with biologically important, guanine-rich sequences of DNA (owing to the 2, 6-standing F atoms which hinder the drug-target inter action) must be assumed as cause of its marginal cytotoxicity.

• Authors: Sabine Schertl, Rolf W Hartmann, Christine Batzl-Hartmann, Günther Bernhardt, Thilo Spruss, Karin Beckenlehner, Marion Koch, Rudolf Krauser, Richard Schlemmer, Ronald Gust, Helmut Schönenberger
• Journal: Archiv der Pharmazie (Arch Pharm (Weinheim)) Vol. 337 Issue 6 Pg. 349-59 (Jun 2004) ISSN: 0365-6233 [Print] Germany
• PMID: 15188224 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• (1,2-bis(2, 6-difluoro-3-hydroxyphenyl)ethylene-diamine)platinum(II)
• Antineoplastic Agents, Hormonal
• DNA, Neoplasm
• Organoplatinum Compounds

Topics

• Absorption
• Animals
• Antineoplastic Agents, Hormonal (chemistry, pharmacokinetics, pharmacology)
• Cell Death
• Cell Line, Tumor
• DNA, Neoplasm (metabolism)
• Female
• Mammary Neoplasms, Experimental (drug therapy)
• Mice
• Neoplasms, Hormone-Dependent (drug therapy)
• Organoplatinum Compounds (pharmacology)
• Stereoisomerism
• Structure-Activity Relationship