The development of
autolysis in grey brain matter of albino rats was accompanied by desintegration of aminophospholipids with parallel increase of
glycerophosphates (GLP) and
phosphatidic acids (PA) on early stages of incubation and
lysophospholipids (LPL) on later stages. Acute hypobaric hypoxic
hypoxia decreased the level of
phosphatidylethanolamines (PE) with simultaneous accumulation of PA. Previous
hypoxia altered the character of autolytic reorganizations of
phospholipids. Oscillatory reciprocal reorganizations in the system PE > PS (
phosphatidylserine) were observed at early stage (1 h) and at late stages of
autolysis (24 h). At the same time increased transformation of
phosphatidylcholines (PC) into
sphingomyelins (SM) with simultaneous accumulation GLP was registered. During
autolysis of brain white matter of control rats opposite oscillatory reorganizations of PE, PC, SM, PA with reduction of PE and simultaneous increase of LPL and PA level after 1 hour of incubation were observed. Reciprocal reactions of biotransformation in system PS > PE were revealed at 4th hour. Previous hypobaric hypoxic
hypoxia reduced the level of total
phospholipids as well as PS at simultaneous increase of LPL. Acute hypobaric hypoxic
hypoxia increased autolytic transformations in system PC > SM and induced hydrolysis of PE, PC into LPL at late stages of
autolysis.