Abstract | BACKGROUND: METHODS AND RESULTS: In the normal esophageal mucosa, CD55 predominantly stained on the cell membrane of squamous epithelium in the superficial and prickle cell layers, whereas CD46 most intensely stained on the cell membrane in the basal and parabasal cell layers. In contrast to this reciprocal expression of CD55 and CD46, CD59 was broadly distributed on the cell membrane in all layers. In the esophageal squamous cell carcinoma, CD55 staining was intense in the stroma but was negligible in the cancer cells. In contrast, CD46 and CD59 stained almost uniformly on the tumor cell membrane. There was a significant difference in the intensity of the staining of CD55 and CD46 among cells in various layers of normal esophageal mucosa and esophageal carcinoma cells, but not in the staining of CD59. Similar expression patterns of the three complement regulatory proteins in carcinoma cells and in normal epithelium in the basal and parabasal cell layers were observed. CONCLUSIONS:
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Authors | Kimihiro Shimo, Motowo Mizuno, Junichirou Nasu, Sakiko Hiraoka, Chiho Makidono, Hiroaki Okazaki, Kazuhide Yamamoto, Hiroyuki Okada, Teizo Fujita, Yasushi Shiratori |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 19
Issue 6
Pg. 643-7
(Jun 2004)
ISSN: 0815-9319 [Print] Australia |
PMID | 15151618
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, CD
- CD46 protein, human
- CD55 Antigens
- CD59 Antigens
- Complement Inactivator Proteins
- Membrane Cofactor Protein
- Membrane Glycoproteins
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Topics |
- Antigens, CD
(metabolism)
- CD55 Antigens
(metabolism)
- CD59 Antigens
(metabolism)
- Carcinoma, Squamous Cell
(metabolism)
- Case-Control Studies
- Complement Inactivator Proteins
(metabolism)
- Esophageal Neoplasms
(metabolism)
- Esophagus
(metabolism)
- Female
- Humans
- Immunohistochemistry
- Male
- Membrane Cofactor Protein
- Membrane Glycoproteins
(metabolism)
- Middle Aged
- Mucous Membrane
(metabolism)
- Tissue Distribution
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