Abstract | BACKGROUND: METHODS: We genotyped eight single nucleotide polymorphisms within the gene, four of which had been reported in previous studies, and four identified as informative by our group through direct screening of the gene and genotyping in a sample of cases and control subjects. RESULTS: A significant excess of transmissions was observed for two of the markers, p1635 and p1757, (p =.0009 and.0013, respectively). Analysis of two-, three-, and four-marker haplotypes produced numerous positive results, with six (4% of the total combinations) at p <.001. CONCLUSIONS: These results provide strong support for DTNBP1 as a susceptibility gene for schizophrenia; however, different haplotypes seem to be associated in different studies.
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Authors | George Kirov, Dobril Ivanov, Nigel M Williams, Anna Preece, Ivan Nikolov, Radoi Milev, Svetlinka Koleva, Albena Dimitrova, Draga Toncheva, Michael C O'Donovan, Michael J Owen |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 55
Issue 10
Pg. 971-5
(May 15 2004)
ISSN: 0006-3223 [Print] United States |
PMID | 15121479
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carrier Proteins
- DTNBP1 protein, human
- Dysbindin
- Dystrophin-Associated Proteins
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Topics |
- Bulgaria
(ethnology)
- Carrier Proteins
(genetics)
- Dysbindin
- Dystrophin-Associated Proteins
- Family Health
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Parents
- Polymorphism, Single Nucleotide
- Schizophrenia
(genetics)
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