Adiponectin is inversely related to plasminogen activator inhibitor type 1 in patients with stable exertional angina.

Abstract

Adipose tissue is a secretory organ producing a variety of bioactive substances, such as adiponectin. Adiponectin has antiatherogenic properties while plasminogen activator inhibitor type 1 (PAI-1) is closely involved in the development of atherosclerosis. The relationship between adiponectin and PAI-1 in patients with coronary artery disease (CAD) has not been clarified. This study examined plasma levels of adiponectin and PAI-1 in 64 patients with stable exertional angina (SEA) and 65 patients with the chest pain syndrome (CPS). Plasma log-adiponectin levels were significantly lower in patients with SEA (0.62+/-0.08 micro g/dL) compared to those with CPS (0.86+/-0.05 micro g/dL) (p<0.0001). The plasma levels of log-PAI-1 were significantly higher in patients with SEA (1.23+/-0.18 ng/mL) compared to those with CPS (1.15+/-0.22 ng/mL) (p<0.05). Plasma log-adiponectin levels correlated negatively with diabetes mellitus (DM), body mass index (BMI), log-PAI-1 (r=-0.284, p<0.001), triglyceride (TG), and remnant-like particles cholesterol (RLP-C), and positively with high-density lipoprotein cholesterol (HDL-C) levels. Plasma levels of log-PAI-1 correlated positively with DM, BMI,TG and RLP-C levels, and negatively with HDL-C levels. Multiple logistic regression analysis identified sex, angina pectoris, and PAI-1 as independent determinants of hyperadiponectinemia (p<0.05). Adiponectin is inversely related to PAI-1. DM, BMI,TG, HDL-C, and RLP-C are common mediators between adiponectin and PAI-1, and treatment for common mediators may prevent the development of CAD by reducing PAI-1 and increasing adiponectin levels.

• Authors: Hidetomo Maruyoshi, Sunao Kojima, Tohru Funahashi, Shinzo Miyamoto, Jun Hokamaki, Hirofumi Soejima, Tomohiro Sakamoto, Hiroaki Kawano, Michihiro Yoshimura, Akira Kitagawa, Yuji Matsuzawa, Hisao Ogawa
• Journal: Thrombosis and haemostasis (Thromb Haemost) Vol. 91 Issue 5 Pg. 1026-30 (May 2004) ISSN: 0340-6245 [Print] Germany
• PMID: 15116265 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adiponectin
• Intercellular Signaling Peptides and Proteins
• Plasminogen Activator Inhibitor 1

Topics

• Adiponectin
• Adult
• Aged
• Aged, 80 and over
• Angina Pectoris (blood)
• Chest Pain (blood)
• Diabetes Mellitus (blood)
• Female
• Humans
• Intercellular Signaling Peptides and Proteins (analysis)
• Logistic Models
• Male
• Middle Aged
• Plasminogen Activator Inhibitor 1 (blood)
• Sex Factors