Atrial fibrillation following chemotherapy for stage IIIE diffuse large B-cell gastric lymphoma in a patient with myotonic dystrophy (Steinert's disease).

Abstract

The authors describe the unusual association between diffuse B-cell gastric lymphoma and myotonic dystrophy, the most common form of adult muscular dystrophy, and sudden atrial fibrillation following one cycle of doxorubicin-based chemotherapy in the same patient. Atrial fibrillation or other cardiac arrhythmias are unusual complications in patients treated with chemotherapy. The cardiac toxicity intrinsically associated with the aggressive chemotherapy employed could function as a triggering factor for the arrhythmia in the predisposed myocardium of this patient.

• Authors: Liliana Montella, Michele Caraglia, Raffaele Addeo, Raffaele Costanzo, Vincenzo Faiola, Alberto Abbruzzese, Salvatore Del Prete
• Journal: Annals of hematology (Ann Hematol) Vol. 84 Issue 3 Pg. 192-3 (Mar 2005) ISSN: 0939-5555 [Print] Germany
• PMID: 15042318 (Publication Type: Case Reports, Letter)

Chemical References

• Antineoplastic Agents
• Doxorubicin

Topics

• Antineoplastic Agents (adverse effects)
• Atrial Fibrillation (chemically induced)
• Doxorubicin (adverse effects)
• Humans
• Lymphoma, B-Cell (complications, drug therapy, pathology)
• Lymphoma, Large B-Cell, Diffuse (complications, drug therapy, pathology)
• Male
• Middle Aged
• Myotonic Dystrophy (complications)
• Neoplasm Staging
• Stomach Neoplasms (complications, drug therapy, pathology)