Consensus guidelines on anti-cardiolipin antibody testing and reporting.

Abstract

UNLABELLED:

Consensus guidelines on anti-cardiolipin antibody (aCL) testing have been developed to help minimise laboratory variation in the performance and reporting of aCL assays. These guidelines include minimum, optimum and optional recommendations for the following aspects of aCL testing and reporting: (1) isotype of aCL tested; (2) specimen type; (3) controls and assay precision; (4) calibrators; (5) patient samples; (6) rheumatoid factors and IgM aCL testing; (7) reporting of results; (8) cut-off values; and (9) interpretative comments.

ABBREVIATIONS:

aCL, anti-cardiolipin antibodies; APS, anti-phospholipid antibody syndrome; ASCIA, Australasian Society of Clinical Immunology and Allergy; ASTH, Australasian Society of Thrombosis and Haemostasis; beta2-GPI=beta2-glycoprotein I; ELISA, enzyme-linked immunosorbent assay; NCCLS, National Committee for Clinical Laboratory Standards; HSANZ, Haematology Society of Australia and New Zealand; QAP, Quality Assurance Program; RCPA, Royal College of Pathologists of Australasia; %CV, inter-assay inter-run coefficient of variation.

• Authors: Richard C W Wong, David Gillis, Stephen Adelstein, Karl Baumgart, Emmanuel J Favaloro, Michelle J Hendle, Paul Homes, Wendy Pollock, Stewart Smith, Richard H Steele, Allan Sturgess, Robert J Wilson
• Journal: Pathology (Pathology) Vol. 36 Issue 1 Pg. 63-8 (Feb 2004) ISSN: 0031-3025 [Print] England
• PMID: 14757559 (Publication Type: Guideline, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Anticardiolipin

Topics

• Antibodies, Anticardiolipin (blood)
• Australia
• Enzyme-Linked Immunosorbent Assay (methods, standards)
• Humans
• New Zealand
• Quality Assurance, Health Care (standards)
• Reproducibility of Results
• Sensitivity and Specificity