Polymorphisms in the dopamine D5 receptor (DRD5) gene and ADHD.

Abstract

There is considerable evidence to support a role of dopamine-related genes in the molecular aetiology of attention-deficit hyperactivity disorder (ADHD). A microsatellite located near the dopamine D5 receptor (DRD5) gene has been associated with ADHD in a number of studies, but other polymorphisms within the vicinity of this gene have not been examined. In this study we genotyped three microsatellites spanning the DRD5 region in a large clinical sample. Overall, we found little evidence to support a role for DRD5 in ADHD. We found no evidence of association with either the previously associated DRD5 marker, or a repeat in the promoter region of the gene. We did, however, find significant association for an allele of D4S615, a dinucleotide repeat located 131 kb 3' of DRD5 that has been previously associated with schizophrenia. A global test incorporating all alleles of this marker, however, was not significant and thus this finding needs replication before any conclusions can be made.

• Authors: Jonathan Mill, Sarah Curran, Sandra Richards, Eric Taylor, Philip Asherson
• Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics (Am J Med Genet B Neuropsychiatr Genet) Vol. 125B Issue 1 Pg. 38-42 (Feb 15 2004) ISSN: 1552-4841 [Print] United States
• PMID: 14755441 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2003 Wiley-Liss, Inc.

Chemical References

• DRD5 protein, human
• Receptors, Dopamine D1
• Receptors, Dopamine D5

Topics

• Attention Deficit Disorder with Hyperactivity (genetics)
• Female
• Genetic Predisposition to Disease
• Humans
• Linkage Disequilibrium (genetics)
• Male
• Minisatellite Repeats (genetics)
• Polymorphism, Genetic (genetics)
• Receptors, Dopamine D1 (genetics)
• Receptors, Dopamine D5
• Schizophrenia (genetics)