Abstract | OBJECTIVE: To examine a large population with idiopathic generalised epilepsy ( IGE), and estimate the overall remission rates for the IGEs and subsyndromes in a clinic based sample. Remission rates on valproate, lamotrigine, topiramate, and combinations of these antiepileptic drugs were estimated and factors predicting outcome examined. METHODS: All patients with IGE were identified from a computerised database and EEG records at large adult and paediatric epilepsy clinics. Data were recorded retrospectively on demographics and clinical information, seizure types and syndrome diagnosis, antiepileptic drug treatment details, and remission rates. RESULTS: CONCLUSIONS:
Valproate may be the most effective antiepileptic drug in the treatment of the IGEs. Combination therapy should be initiated if an adequate trial of valproate monotherapy is not effective, rather than switching to alternative monotherapy. Antiepileptic drug treatment needs to be lifelong in many adult patients with IGE.
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Authors | A Nicolson, R E Appleton, D W Chadwick, D F Smith |
Journal | Journal of neurology, neurosurgery, and psychiatry
(J Neurol Neurosurg Psychiatry)
Vol. 75
Issue 1
Pg. 75-9
(Jan 2004)
ISSN: 0022-3050 [Print] England |
PMID | 14707312
(Publication Type: Journal Article)
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Chemical References |
- Anticonvulsants
- Triazines
- Topiramate
- Fructose
- Valproic Acid
- Lamotrigine
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Topics |
- Adolescent
- Adult
- Anticonvulsants
(pharmacology, therapeutic use)
- Child
- Child, Preschool
- Databases, Factual
- Electroencephalography
- Epilepsy
(drug therapy, pathology)
- Female
- Fructose
(analogs & derivatives, pharmacology, therapeutic use)
- Humans
- Lamotrigine
- Male
- Retrospective Studies
- Topiramate
- Treatment Outcome
- Triazines
(pharmacology, therapeutic use)
- Valproic Acid
(pharmacology, therapeutic use)
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