Chagas' disease contributes significantly to cardiovascular morbidity and mortality in several Latin-American countries. Previous studies have reported the effect of the
human leukocyte antigen (HLA) molecules in the immune response regulation of
Trypanosoma cruzi infection, and the association of
HLA antigens with heart damage. We studied the major histocompatibility complex (MHC) class I (
HLA-A and
HLA-B), and class II (
HLA-DR) genes in a sample of 66 serologically positive individuals with and without
cardiomyopathy, and in 127 healthy controls. The total group of seropositive individuals revealed increased frequencies of
HLA-B39 (pc=4.3x10(-5), odds ratio [OR]=3.35) and DR4 (pc=1.8x10(-5), OR=2.91) when compared to healthy controls. Increased frequencies of HLA-A68 and
HLA-B39 were found in asymptomatic individuals when compared to patients with
cardiomyopathy (pc=0.014, OR=4.99 and pc=0.001, OR=4.46, respectively). Also, patients with
cardiomyopathy exhibited increased frequency of
HLA-B35 when compared to healthy controls (pc=0.048, OR=2.56). The
HLA-DR16 frequency was increased in patients with
cardiomyopathy compared with asymptomatic individuals (pc=0.05, OR=No determined) and healthy controls (pc=0.02, OR=5.0). The results suggest that MHC alleles might be associated with the development of
chronic infection and with heart damage in
Chagas' disease.
HLA-DR4 and
HLA-B39 could be associated directly with the
infection by T. cruzi, whereas,
HLA-DR16 could be marker of susceptibility to heart damage and HLA-A68 might confer protection to develop
cardiomyopathy.