Abstract | BACKGROUND: Serum contains noncholesterol sterols, which are reliable markers of cholesterol metabolism, but their presence and importance in different lipoproteins have been insufficiently studied. MATERIALS AND METHODS: RESULTS: At baseline, approximately 14% of serum squalene was transported by VLDL, 12% by IDL, 40% by LDL and 30% by HDL. The respective values for the noncholesterol sterols were approximately 8, 4, 61 and 26%. The squalene to cholesterol ratios were highest in VLDL and IDL, those of cholestanol, desmosterol and absorption marker sterols were gradually higher, and that of lathosterol lower from VLDL to HDL. Atorvastatin reduced LDL cholesterol by approximately 50%, decreased the absolute cholesterol synthesis and turnover by approximately 40%, but increased significantly the fractional and mass absorption of cholesterol. In accordance with the fecal data, the ratios of the precursor sterols to cholesterol were reduced (-50%), but those of squalene (+48%) and the absorption sterols increased (e.g. 2.6-fold for sitosterol) similarly in each lipoprotein, but progressively from VLDL to HDL. CONCLUSIONS:
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Authors | T A Miettinen, H Gylling |
Journal | European journal of clinical investigation
(Eur J Clin Invest)
Vol. 33
Issue 11
Pg. 976-82
(Nov 2003)
ISSN: 0014-2972 [Print] England |
PMID | 14636301
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticholesteremic Agents
- Cholesterol, LDL
- Heptanoic Acids
- Lipids
- Lipoproteins
- Phytosterols
- Pyrroles
- Squalene
- Cholesterol
- Atorvastatin
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Topics |
- Aged
- Anticholesteremic Agents
(therapeutic use)
- Atorvastatin
- Cholesterol
(biosynthesis, blood)
- Cholesterol, LDL
(blood)
- Diabetes Mellitus, Type 2
(blood, complications)
- Feces
(chemistry)
- Heptanoic Acids
(therapeutic use)
- Humans
- Hypercholesterolemia
(blood, complications, drug therapy)
- Intestinal Absorption
- Lipids
(blood)
- Lipoproteins
(blood)
- Liver
(physiopathology)
- Male
- Middle Aged
- Phytosterols
(blood)
- Pyrroles
(therapeutic use)
- Squalene
(blood)
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