Successful use of 111In-pentetrotide scintigraphy for localizing ectopic adrenocorticotropin-producing bronchial carcinoid tumor in a patient with Cushing's syndrome.

Abstract

A 34-year-old man was diagnosed with clinical Cushing's syndrome based on circadian fluctuation of plasma adrenocorticotropin and serum cortisol levels and Liddle's-method. The presence of ectopic adrenocorticotropin production was suspected. Urine 5-hydroxyindoleaceturic acid level was high. Chest computed-tomography scan revealed a mass in the right upper lung. 111In-pentetrotide scintigraphy demonstrated marked accumulation in the right upper lung. We suspected an adrenocorticotropin-producing bronchial carcinoid. Plasma adrenocorticotropin and serum cortisol levels decreased immediately following resection of the tumor. Adrenocorticotropin production by tumor cells was confirmed by immunohistochemistry. This case indicates 111In-pentetrotide scintigraphy could be successfully used to identify and localize ectopic adrenocorticotropin-producing bronchial carcinoid.

• Authors: Ken Kishida, Makoto Moriwaki, Jun-ichiro Miyagawa, Kohei Okita, Takashi Kondo, Kimiko Itoh, Satoshi Umemura, Junji Kozawa, Hiromi Iwahashi, Tohru Yoshizumi, Akihisa Imagawa, Kazuya Yamagata, Takao Maruyama, Hiroyuki Toyoshima, Eiji Kurokawa, Tohru Funahashi, Yuji Matsuzawa
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 42 Issue 10 Pg. 996-1005 (Oct 2003) ISSN: 0918-2918 [Print] Japan
• PMID: 14606715 (Publication Type: Case Reports, Journal Article)

Chemical References

• Indium Radioisotopes
• Somatostatin
• pentetreotide

Topics

• ACTH Syndrome, Ectopic (diagnostic imaging, etiology)
• Adult
• Bronchial Neoplasms (complications, diagnostic imaging, metabolism)
• Carcinoid Tumor (complications, diagnostic imaging, metabolism)
• Cushing Syndrome (etiology)
• Humans
• Indium Radioisotopes
• Male
• Radionuclide Imaging
• Somatostatin (analogs & derivatives)