[The mechanism of action of the bioflavonoid lespeflan and the antihypoxant TB-4 on nitrogen metabolism in animals with acute kidney failure].

Abstract

The changes in the levels of urea and creatinine caused by the new native preparation lespeflanum and the antihypoxant TB-4 were studied in animal experiments. The agents tested produced a significant hypoazotemic effect in acute renal failure. Lespeflanum showed diuretic and natriuretic effects in healthy animals, elevated plasma aldosterone levels and decreased hepatic arginase activity. There was a normalization of thioldisulfide metabolism in patients treated with lespeflanum and TB-4. The hypoazotemic effect of lespeflanum was due both to its anabolic and anticatabolic effects. Lespeflanum is recommended for wide clinical application to treat patients with chronic renal failure.

• Authors: V G Guliaev, P P Denisenko, V I Glyzin, Iu I Ivanov, I F Meshchishen
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1992 Jul-Aug Vol. 55 Issue 4 Pg. 20-2 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: K mekhanizmu deĭstviia bioflavonoida lespeflana i antigipoksanta TB-4 na azotistyĭ obmen u zhivotnykh s ostroĭ pochechnoĭ nedostatochnost'iu.
• PMID: 1458179 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antioxidants
• Diuretics
• Flavonoids
• Thiobarbiturates
• thiobarbituric acid
• Nitrogen

Topics

• Acute Kidney Injury (blood, drug therapy, physiopathology)
• Animals
• Antioxidants (pharmacology, therapeutic use)
• Diuretics (pharmacology, therapeutic use)
• Drug Evaluation, Preclinical
• Drug Synergism
• Drug Therapy, Combination
• Flavonoids (pharmacology, therapeutic use)
• Kidney (drug effects, physiopathology)
• Natriuresis (drug effects)
• Nitrogen (blood)
• Rats
• Thiobarbiturates (pharmacology, therapeutic use)