NORADRENALINE STORES IN NERVE TERMINALS OF THE SPLEEN: CHANGES DURING HEMORRHAGIC SHOCK.

Abstract

In dogs subjected to hemorrhagic shock, a marked decrease in the noradrenaline content of the sympathetic nerve terminals in the normally innervated spleen is revealed by means of a histochemical fluorescence method. Deprivation of the sympathetic impulse-flow to the tissue immediately before the animals are subjected to shock prevents this depletion. The results support the hypothesis that the vasoconstriction which occurs during shock is due to the effect of noradrenaline released locally in the tissues, and not to circulating noradrenaline.

• Authors: A B DAHLSTROEM, B E ZETTERSTROEM
• Journal: Science (New York, N.Y.) (Science) Vol. 147 Issue 3665 Pg. 1583-5 (Mar 26 1965) ISSN: 0036-8075 [Print] United States
• PMID: 14260376 (Publication Type: Journal Article)

Chemical References

• Norepinephrine

Topics

• Animals
• Denervation
• Dogs
• Fluorescence
• Histocytochemistry
• Muscle, Smooth
• Muscles
• Nerve Endings
• Neurochemistry
• Norepinephrine
• Research
• Shock, Hemorrhagic
• Spleen
• Sympathetic Nervous System
• Vasomotor System