Poliomyelitis

An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)

Also Known As:

Polio; Infantile Paralysis; Paralysis, Infantile; Polios; Encephalitis, Polio; Epidemic Acute Poliomyelitis; Polio Encephalitis; Poliomyelitis, Acute; Acute Poliomyelitis; Acute Poliomyelitis, Epidemic; Nonpoliovirus Poliomyelitis; Poliomyelitides, Preparalytic; Poliomyelitis, Epidemic Acute; Preparalytic Poliomyelitis; Poliomyelitis, Nonpoliovirus; Poliomyelitis, Preparalytic

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Virus Diseases: 1376

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RNA Virus Infections: 46

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Picornaviridae Infections: 39

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Enterovirus Infections: 161

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Poliomyelitis: 3502

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Central Nervous System Viral Diseases: 10

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Poliomyelitis: 3502

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Myelitis: 266

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Poliomyelitis: 3502

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Nervous System Diseases: 3643

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Central Nervous System Diseases: 1005

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Spinal Cord Diseases: 1403

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Poliomyelitis: 3502

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Myelitis: 266

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Poliomyelitis: 3502

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Central Nervous System Infections: 250

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Myelitis: 266

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Poliomyelitis: 3502

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Central Nervous System Viral Diseases: 10

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Poliomyelitis: 3502

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Myelitis: 266

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Poliomyelitis: 3502

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Neuromuscular Diseases: 768

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Motor Neuron Disease: 894

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Poliomyelitis: 3502

Authors	A GRAFE, R B KUHN
Journal	Arzneimittel-Forschung (Arzneimittelforschung) Vol. 12 Pg. 392-5 (Apr 1962) ISSN: 0004-4172 Not Available
PMID	13900987 (Publication Type: Journal Article)
Chemical References	Vaccines Aluminum
Topics	Aluminum (pharmacology) Diphtheria (immunology) Poliomyelitis (immunology) Tetanus (immunology) Vaccines (pharmacology)

[The potentiation of vaccines by aluminum oxide adsorption. 2. Aluminum oxide-poliomyelitis-diphtheria-tetanus vaccine.]