Abstract | UNLABELLED: A decrease in the myocardial extraction or excretion of lactates indicates its hypoxia. The authors analyzed changes in the extraction of lactates, non- esterified fatty acids ( NEFA) and their fractions: C 14:0, C 16:0, C 16:1, C 18:1, C 18:2 in a group of 15 patients with dilated cardiomyopathy (DC) and in 10 controls at rest and after the cold pressor test ( CPT). At rest, 5 patients with DC produced lactates or extracted less than 10%. During CPT, production of lactates was observed in another four patients (mean values: 17.9 +/- 32.6% vs 24.5 +/- 5.2%, ns). NEFA extraction was found in the DC group: 18.4 +/- 20.6% vs. 13.9 +/- 33.3% /p < 0.05/). The acids involved were C 14:0, C 16:0, C 16:1 and C 18:0. In the controls, NEFA extraction did not change significantly: 12.1 +/- 8.6% vs 29.7 +/- 33.2%. CONCLUSIONS: 1. In part of patients with DC, production of lactates was found. The degree of lactate excretion increased due to CPT; 2. In DC, adrenergic stimulus ( CPT) impairs the myocardial utilization of NEFA. This applied mainly to myristic acids, palmitic acid, palmitooleic acid and stearic acid; 3. This phenomenon probably is a result of profound functional and morphological damage to the mitochondrial system in DC.
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Authors | J S Dubiel, K Zmudka, A Surdacki, T Brzostek, J Jaskiewicz, P P Dimitrow, J P Dubiel |
Journal | Cor et vasa
(Cor Vasa)
Vol. 34
Issue 5-6
Pg. 373-81
( 1992)
ISSN: 0010-8650 [Print] Czech Republic |
PMID | 1339710
(Publication Type: Journal Article)
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Chemical References |
- Fatty Acids, Nonesterified
- Lactates
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Topics |
- Adult
- Arousal
(physiology)
- Cardiomyopathy, Dilated
(blood)
- Cold Temperature
- Energy Metabolism
(physiology)
- Fatty Acids, Nonesterified
(blood)
- Female
- Hemodynamics
(physiology)
- Humans
- Lactates
(blood)
- Male
- Middle Aged
- Myocardial Ischemia
(blood)
- Myocardium
(metabolism)
- Oxygen Consumption
(physiology)
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