Diverse classes of T-cell lymphomas arise in T-lymphocyte-inductive epitheliomas of the mouse salivary gland.

Abstract

During the course of serial transplantations of polyomavirus-induced C3H-Bittner salivary gland epitheliomas in F1-hybrid mice, three tumor sublines were found which gave rise to T-cell lymphomas of host origin. The lymphomas resembled spontaneous AKR/J thymic lymphomas in their expression of lymphoid differentiation antigens, and they may represent sequential stages in the differentiation of immature T lymphocytes. We found no evidence that polyomavirus directly induced the lymphomas, rather, the lymphomagenic events paralleled those which occur in spontaneous AKR/J thymic lymphomas.

• Authors: F A Harrod, J R Kettman
• Journal: Leukemia research (Leuk Res) Vol. 16 Issue 9 Pg. 899-917 (Sep 1992) ISSN: 0145-2126 [Print] England
• PMID: 1328771 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Biomarkers
• Biomarkers, Tumor
• DNA, Neoplasm
• DNA

Topics

• Animals
• Biomarkers (analysis)
• Biomarkers, Tumor (analysis)
• Blotting, Southern
• DNA (analysis)
• DNA, Neoplasm (analysis)
• Genome, Viral
• Lymphocyte Activation (physiology)
• Lymphoma, T-Cell (chemistry, immunology, microbiology, pathology)
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C3H
• Mice, Nude
• Neoplasm Transplantation
• Phenotype
• Polyomavirus (genetics)
• Salivary Gland Neoplasms (chemistry, immunology, microbiology, pathology)
• T-Lymphocytes (chemistry, immunology, physiology)
• Thymus Gland (immunology)
• Thymus Neoplasms (immunology, microbiology, pathology)