Abstract | OBJECTIVES: METHODS: Participants were identified from the University of Michigan Prostate Cancer Genetics Project, a family-based study of inherited prostate cancer susceptibility. Of the 141 eligible affected and unaffected sons of men with prostate cancer, 124 (88%) completed a mailed questionnaire regarding serum PSA testing and DRE history. RESULTS: Among unaffected men, 95% reported ever having had a PSA test, and 97% ever having had a DRE, with most initial tests occurring between the ages of 40 and 60 years. No significant difference in the mean age at first PSA test or DRE between the affected and unaffected men was observed. Affected men were significantly more likely than unaffected men to have a first PSA level greater than 2.5 ng/mL (P = 0.006), but not greater than 4.0 ng/mL (P = 0.614). CONCLUSIONS: Most men with a family history of prostate cancer are undergoing early detection testing. The differences in early detection testing practices do not appear to account for the difference in affection status among the sons of men with prostate cancer.
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Authors | Cathryn H Bock, Patricia A Peyser, Stephen B Gruber, Susan E Bonnell, Karen L Tedesco, Kathleen A Cooney |
Journal | Urology
(Urology)
Vol. 62
Issue 3
Pg. 470-5
(Sep 2003)
ISSN: 1527-9995 [Electronic] United States |
PMID | 12946749
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Prostate-Specific Antigen
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Topics |
- Adult
- Age Distribution
- Aged
- Aged, 80 and over
- Biopsy
- Biopsy, Needle
- Black People
- Diagnosis, Differential
- Humans
- Male
- Mass Screening
(statistics & numerical data)
- Medical History Taking
- Michigan
(epidemiology)
- Middle Aged
- Neoplasm Staging
- Palpation
- Physical Examination
- Pilot Projects
- Population Surveillance
- Predictive Value of Tests
- Prostate-Specific Antigen
(analysis)
- Prostatic Hyperplasia
(epidemiology)
- Prostatic Neoplasms
(diagnosis, epidemiology, genetics)
- Prostatitis
(epidemiology)
- Risk Management
- Sensitivity and Specificity
- White People
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