[Cell differentiation in human melanoma cells caused by dicarbamine (ultrastructural investigation)].

Abstract

The effects of dicarbamine (r) and polytransretinoic acid (PTRA) on human melanoma MEL-6 transplanted into Balb/c nude female mice have been compared by histological and electron microscopic procedures. It was discovered that long-term administration of 1.5 mg/kg dicarbamine caused melanoma MEL-6 cells to undergo terminal differentiation. As a result, the number of melanosome-containing cells was 3-4 times and the number of melanosomes in them--5 times those in intact controls. Dicarbamine effect was double that of PTRA.

• Authors: N T Raĭkhlin, V E Nebol'sin, G A Zheltukhina, I P Bryzgalov, Iu D Sorokina, N V Andronova, L A Sedakova, E A Smirnova, E M Treshchalina
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 49 Issue 3 Pg. 351-8 ( 2003) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Differentsirovka kletok melanomy cheloveka pod deĭstviem preparata dikarbamin (ul'trastrukturnoe issledovanie).
• PMID: 12926220 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Carbamates
• Melanins
• Tretinoin

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Carbamates (pharmacology)
• Cell Differentiation (drug effects)
• Humans
• Immunohistochemistry
• Melanins (analysis)
• Melanoma, Experimental (drug therapy, ultrastructure)
• Melanosomes (chemistry, drug effects)
• Mice
• Mice, Nude
• Microscopy, Electron
• Neoplasm Transplantation
• Tretinoin (pharmacology)