Abstract | BACKGROUND: METHODS: Twenty-seven mongrel dogs were anaesthetized with pentobarbital. Bronchoconstriction was elicited with methacholine (0.5 microg kg(-1)+5.0 microg kg(-1) min(-1); Mch group, n=7) or serotonin (10 microg kg(-1)+1 mg kg(-1) h(-1); 5HT group, n=20), and assessed as percentage changes in bronchial cross-sectional area (BCA, basal=100%) using a bronchoscope. In the 5HT group, dogs were subdivided into four groups of five each: S-5HT, I-5HT, 5HT-S and 5HT-A. In the S-5HT and I-5HT groups, 30 min before serotonin infusion dogs were given saline and indomethacin respectively at 5 mg kg(-1) i.v. In all groups, 30 min after bronchoconstrictor infusion started, dogs were given thiopental at doses between 0 (saline) and 20 mg kg(-1). In the 5HT-S and 5HT-A groups, dogs were given saline or atropine 0.2 mg kg(-1) i.v. 5 min after thiopental 20 mg kg(-1). RESULTS: CONCLUSION:
|
Authors | S Kabara, K Hirota, H Yoshioka, T Kudo, H Ishihara, A Matsuki |
Journal | British journal of anaesthesia
(Br J Anaesth)
Vol. 91
Issue 3
Pg. 379-84
(Sep 2003)
ISSN: 0007-0912 [Print] England |
PMID | 12925478
(Publication Type: Journal Article)
|
Chemical References |
- Anesthetics, Intravenous
- Bronchoconstrictor Agents
- Serotonin Antagonists
- Methacholine Chloride
- Serotonin
- Thiopental
- Norepinephrine
- Indomethacin
- Epinephrine
|
Topics |
- Anesthetics, Intravenous
(pharmacology)
- Animals
- Bronchoconstriction
(drug effects)
- Bronchoconstrictor Agents
(pharmacology)
- Dogs
- Dose-Response Relationship, Drug
- Drug Interactions
- Epinephrine
(blood)
- Indomethacin
(pharmacology)
- Methacholine Chloride
(pharmacology)
- Norepinephrine
(blood)
- Serotonin
(pharmacology)
- Serotonin Antagonists
(pharmacology)
- Thiopental
(pharmacology)
|