Tissue Molecular Anatomy Project (TMAP): an expression database for comparative cancer proteomics.

Abstract

By mining publicly accessible databases, we have developed a collection of tissue-specific predictive protein expression maps as a function of cancer histological state. Data analysis is applied to the differential expression of gene products in pooled libraries from the normal to the altered state(s). We wish to report the initial results of our survey across different tissues and explore the extent to which this comparative approach may help uncover panels of potential biomarkers of tumorigenesis which would warrant further examination in the laboratory.

• Authors: Djamel Medjahed, Brian T Luke, Tawady S Tontesh, Gary W Smythers, David J Munroe, Peter F Lemkin
• Journal: Proteomics (Proteomics) Vol. 3 Issue 8 Pg. 1445-53 (Aug 2003) ISSN: 1615-9853 [Print] Germany
• PMID: 12923770 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Topics

• Databases, Protein
• Expressed Sequence Tags
• Neoplasms (metabolism)
• Proteomics