Infection,
thrombosis, and
stenosis are among the most frequent complications associated with blood-contacting
catheters. These problems are usually related to surface properties of the base
catheter material. Surface treatment processes, such as ion implantation and ion beam assisted deposition (IBAD) and microdomain structured surfaces, can be used to mitigate such complications. This study evaluated
silver coated and implanted large bore
catheters used for extracorporeal detoxification. In a 186 patient prospective study, 225 large bore
catheters were inserted into the internal jugular or subclavian veins. Eighty-five surface-treated
catheters (Spi-Argent, Spire Corporation, Bedford, MA, USA) and 28
catheters with surface treatment (Spi-
Silicone, Spire Corporation) were inserted in 90 patients. One hundred and twelve untreated
catheters placed in 96 patients served as controls, After removal, the
catheters were cultured for bacterial colonization using standard microbiologic assays. They also were examined using a scanning electron microscope (SEM). Bacterial colonization was observed in 8% of the treated
catheter compared with 46.4% of untreated
catheters. The SEM investigations showed all treated
catheters to possess low thrombogenicity.
Catheters with microdomain structured surfaces showed same results in preliminary observation. The surface treatments of the large bore
catheters can be used to improve
thrombus and
infection resistance of blood contacting
catheters.