Abstract | BACKGROUND:
Sildenafil is an effective and widely used therapeutic agent for erectile dysfunction. Deaths have been reported due to sildenafil use and most of them are attributed to concurrent use of nitrates. However, the effects of sildenafil on QT intervals, QT dispersion, and the possible risk of ventricular arrhythmia have not been studied before. Our aim in this study was to evaluate the effect of sildenafil citrate on QT intervals and QT dispersion. METHODS: RESULTS: Mean age of the patients was 54 +/- 12 years. The mean heart rate did not differ significantly between the three ECG examinations. The corrected and uncorrected maximum and minimum QT intervals were not significantly different between the three ECG examinations. The QT dispersion and corrected QT dispersion before and 1 hour and 4 hours after sildenafil ingestion were 31 +/- 9 ms, 36 +/- 10 ms; 32 +/- 11 ms, 37 +/- 14 ms; 27 +/- 8 ms, 32 +/- 9 ms, respectively (P > 0.05). CONCLUSIONS:
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Authors | Mete Alpaslan, Ersel Onrat, Murat Samli, Cetin Dincel |
Journal | Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
(Ann Noninvasive Electrocardiol)
Vol. 8
Issue 1
Pg. 14-7
(Jan 2003)
ISSN: 1082-720X [Print] United States |
PMID | 12848808
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Piperazines
- Purines
- Sulfones
- Sildenafil Citrate
- 3',5'-Cyclic-GMP Phosphodiesterases
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Topics |
- 3',5'-Cyclic-GMP Phosphodiesterases
(pharmacology)
- Adult
- Aged
- Electrocardiography
- Heart Conduction System
(drug effects)
- Heart Rate
(drug effects)
- Humans
- Male
- Middle Aged
- Piperazines
(pharmacology)
- Purines
- Sildenafil Citrate
- Sulfones
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