Abstract | BACKGROUND: METHOD: FINDINGS:
EPC-K1 significantly reduced both the cerebral TBARS level and the infarct size in a rat model of transient focal cerebral ischaemia. These results indicate that EPC-K1 administration during the early stages of reperfusion ameliorates ischaemic brain injury by inhibiting lipid peroxidation. INTERPRETATION: This report is the first to describe the protective mechanism of EPC-K1 by measuring both the TBARS level and infarct size in a rat model of transient focal cerebral ischaemia, and may suggest a potential clinical approach for the treatment of ischaemic cerebrovascular disease.
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Authors | N Kato, K Yanaka, S Nagase, A Hirayama, T Nose |
Journal | Acta neurochirurgica
(Acta Neurochir (Wien))
Vol. 145
Issue 6
Pg. 489-93; discussion 493
(Jun 2003)
ISSN: 0001-6268 [Print] Austria |
PMID | 12836074
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Free Radicals
- Reactive Oxygen Species
- Thiobarbituric Acid Reactive Substances
- Vitamin E
- potassium ascorbyl tocopheryl phosphate
- Ascorbic Acid
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Topics |
- Animals
- Antioxidants
(pharmacology)
- Ascorbic Acid
(analogs & derivatives, pharmacology)
- Brain Ischemia
(complications, drug therapy, pathology)
- Disease Models, Animal
- Free Radicals
- Lipid Peroxidation
- Male
- Rats
- Rats, Sprague-Dawley
- Reactive Oxygen Species
- Reperfusion Injury
(drug therapy, pathology)
- Thiobarbituric Acid Reactive Substances
(analysis)
- Vitamin E
(analogs & derivatives, pharmacology)
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