Alteration of the striatal dopaminergic system in human narcolepsy.

Abstract

Striatal D2/D3 dopaminergic receptors have been proposed to play a role in cataplexy. The authors studied the striatal presynaptic dopamine transporter and postsynaptic D2-receptors in seven patients with narcolepsy and seven control subjects using [123I](N)-(3-iodopropene-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl)tropane and [123I](S)-2-hydroxy-3-iodo-6-methoxy-([1-ethyl-2-pyrrolidinyl]methyl)benzamide SPECT. D2-receptor binding was elevated in narcolepsy (p = 0.017) and correlated with the frequency of cataplectic and sleep attacks (R > or = 0.844, p < or = 0.017). The human striatal dopaminergic system is altered in vivo in narcolepsy/cataplexy.

• Authors: I Eisensehr, R Linke, K Tatsch, H von Lindeiner, B Kharraz, F J Gildehaus, R Eberle, T Pollmacher, A Schuld, S Noachtar
• Journal: Neurology (Neurology) Vol. 60 Issue 11 Pg. 1817-9 (Jun 10 2003) ISSN: 1526-632X [Electronic] United States
• PMID: 12796537 (Publication Type: Journal Article)

Chemical References

• Benzamides
• Dopamine Plasma Membrane Transport Proteins
• Iodine Radioisotopes
• Membrane Glycoproteins
• Membrane Transport Proteins
• Nerve Tissue Proteins
• Pyrrolidines
• Receptors, Dopamine D2
• Tropanes
• N-(3-iodopropen-1-yl)-2-carbomethoxy-3-(4-chlorophenyl)tropane
• 3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide

Topics

• Aged
• Benzamides
• Corpus Striatum (chemistry)
• Dopamine Plasma Membrane Transport Proteins
• Female
• Humans
• Iodine Radioisotopes
• Magnetic Resonance Imaging
• Male
• Membrane Glycoproteins
• Membrane Transport Proteins (analysis)
• Middle Aged
• Narcolepsy (diagnosis, metabolism)
• Nerve Tissue Proteins
• Pyrrolidines
• Receptors, Dopamine D2 (analysis)
• Tomography, Emission-Computed, Single-Photon
• Tropanes