Liver ischemia: apoptosis as a central mechanism of injury.

Abstract

Injuries due to cold and warm (normothermic) ischemia remain an important source of morbidity and mortality in liver surgery and transplantation. While the mechanisms of injury are complex, involving apoptotic and necrotic types of cell death, accumulating evidence points to a central role for various apoptotic pathways in mediating cell death following ischemia. A number of antiapoptotic strategies have been shown to confer a high degree of protection, including improved animal survival following long ischemic insult. The future may lie in the identification of practical and effective antiapoptotic strategies to enhance tolerance to ischemic injury.

• Authors: Hannes A Rüdiger, Rolf Graf, Pierre-Alain Clavien
• Journal: Journal of investigative surgery : the official journal of the Academy of Surgical Research (J Invest Surg) 2003 May-Jun Vol. 16 Issue 3 Pg. 149-59 ISSN: 0894-1939 [Print] United States
• PMID: 12775431 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)

Topics

• Animals
• Apoptosis
• Humans
• Liver Diseases (pathology, surgery)
• Liver Transplantation
• Reperfusion Injury (pathology)