The efficacy of permethrin-treated bed nets on child mortality and morbidity in western Kenya II. Study design and methods.

Abstract

This paper describes the study design and methods used in a large community-based, group-randomized, controlled trial of permethrin-treated bed nets (ITNs) in an area with intense, perennial malaria transmission in western Kenya conducted between 1996 and 1999. A multi-disciplinary framework was used to explore the efficacy of ITNs in the reduction of all-cause mortality in children less than five years old, the clinical, entomologic, immunologic, and economic impact of ITNs, the social and behavioral determinants of ITN use, and the use of a geographic information system to allow for spatial analyses of these outcomes. Methodologic difficulties encountered in such large-scale field trials are discussed.

• Authors: Penelope A Phillips-Howard, Feiko O ter Kuile, Bernard L Nahlen, Jane A Alaii, John E Gimnig, Margarette S Kolczak, Dianne J Terlouw, Simon K Kariuki, Ya Ping Shi, S Patrick Kachur, Allen W Hightower, John M Vulule, William A Hawley
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 68 Issue 4 Suppl Pg. 10-5 (Apr 2003) ISSN: 0002-9637 [Print] United States
• PMID: 12749480 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Insecticides
• Permethrin

Topics

• Bedding and Linens
• Child
• Delivery of Health Care
• Humans
• Insecticides (pharmacology)
• Kenya (epidemiology)
• Malaria (epidemiology, mortality, prevention & control)
• Patient Care Team
• Permethrin (pharmacology)