Abstract |
The purpose of this study was to evaluate insulin sensitivity, beta-cell function and islet-cell-directed autoimmunity in pregnant women with normal glucose tolerance and gestational diabetes mellitus (GDM). A total of 21 women with normal glucose tolerance and 21 women with GDM were evaluated at 24-36 weeks' gestation. Insulin resistance and beta-cell function were evaluated using the continuous infusion of glucose with model assessment (CIGMA) method, which aims to give a near-physiological stimulus and to evaluate the endogenous insulin and glucose response. Islet-cell autoantibody was positive in one woman with GDM, and glutamic acid decarboxylase autoantibodies were negative in both groups. The calculated CIGMA insulin resistance (CIGMA IR) was 2.04 +/- 1.74 and 1.08 +/- 1.22 in patients with GDM and in control subjects, respectively (p < 0.05). CIGMA percentage beta-cell values were 64.04 +/- 44.55% and 87.07 +/- 52.77% in patients with GDM and control subjects, respectively (p > 0.05). Decreased insulin sensitivity in late pregnancy was more evident in lean GDM subjects with mild hyperglycemia who did not require insulin therapy, and beta-cell function was partially preserved in this group of patients.
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Authors | E Akbay, M B Tiras, I Yetkin, F Törüner, R Ersoy, S Uysal, G Ayvaz |
Journal | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
(Gynecol Endocrinol)
Vol. 17
Issue 2
Pg. 137-42
(Apr 2003)
ISSN: 0951-3590 [Print] England |
PMID | 12737675
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- Blood Glucose
- Insulin
- Glutamate Decarboxylase
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Topics |
- Adult
- Autoantibodies
(blood)
- Autoimmunity
- Blood Glucose
(analysis)
- Body Mass Index
- Diabetes, Gestational
(physiopathology)
- Female
- Gestational Age
- Glucose Tolerance Test
- Glutamate Decarboxylase
(immunology)
- Humans
- Insulin
(blood, metabolism)
- Insulin Resistance
- Insulin Secretion
- Islets of Langerhans
(immunology, physiopathology)
- Obesity
(physiopathology)
- Pregnancy
- Pregnancy Complications
(physiopathology)
- Weight Gain
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