Distribution of monoclonal antiferritin antibody in Kaposi's sarcoma, Hodgkin's disease, and hepatocellular carcinoma.

Abstract

The immunotherapeutic treatment of cancers using antibodies (naked or conjugated to a drug, toxin, or radionuclide) relies upon the preferential expression of a targeted antigen on the cancer cell compared to normal tissues. Polyclonal antiferritin antisera have shown selective distribution and therapeutic efficacy when radiolabeled in Hodgkin's disease and hepatoma. In this immunohistochemical study, we investigated the distribution of ferritin in tumors from 6 patients with Kaposi's sarcoma, 12 patients with Hodkgin's disease, and 9 patients with hepatoma, as well as in selected normal tissues. We found that the monoclonal antiferritin antibody binds primarily to histiocytes in samples from Kaposi's sarcoma and Hodgkin's disease. One hepatocellular carcinoma showed diffuse cytoplasmic staining with ferritin. Deposition of the monoclonal antibody was not detectable in the remaining hepatocellular carcinoma samples.

• Authors: Alan R Yuen, John P Higgins, Robin Baker, Onsi W Kamel, Roger A Warnke, Susan J Knox
• Journal: Human pathology (Hum Pathol) Vol. 34 Issue 4 Pg. 381-4 (Apr 2003) ISSN: 0046-8177 [Print] United States
• PMID: 12733120 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2003 Elsevier Inc. All rights reserved.

Chemical References

• Antibodies, Monoclonal
• Ferritins

Topics

• Antibodies, Monoclonal (immunology)
• Carcinoma, Hepatocellular (chemistry, metabolism, pathology)
• Ferritins (analysis, immunology, metabolism)
• HIV Infections (complications)
• Hodgkin Disease (metabolism, pathology)
• Immunohistochemistry
• Liver Neoplasms (chemistry, metabolism, pathology)
• Sarcoma, Kaposi (chemistry, metabolism, pathology)
• Skin Neoplasms (chemistry, metabolism, pathology)