Association of polymorphisms in human leukocyte antigen class I and transporter associated with antigen processing genes with resistance to human immunodeficiency virus type 1 infection.

Abstract

To examine the relationship of human leukocyte antigen (HLA) class I and transporter associated with antigen processing (TAP) genes with resistance to human immunodeficiency virus type 1 (HIV-1) infection, 100 HIV-seronegative men who had been exposed repeatedly to HIV-1 were compared with 184 men who had seroconverted to HIV positive and had lower risk. In the univariate analysis, the HLA-A2 supertype, excluding A*0201 (HLA-A2/6802 supertype; odds ratio [OR], 4.45; 95% confidence interval [CI], 1.33-4.84; P=.009) was associated with resistance to HIV-1 infection; the effect was the result of the presence of the A*0205 subgroup alleles. Susceptibility was associated in univariate analysis with the B*35 Px alleles (OR, 0.29; 95% CI, 0.08-0.99; P=.037), which suggests that differential preferences for amino acids at the C terminus may influence peptide-binding capacity. TAP2 Ala665 was also associated with resistance (OR, 2.26; 95% CI, 1.35-3.79; P=.002), perhaps because of its higher efficiency in transporting peptides, thus eliciting a greater CD8(+) T cell response, or because of linkage disequilibrium. In multivariate logistic analysis, only the A*0205 subgroup (OR, 5.56; 95% CI, 1.34-23.10; P=.018) and the TAP2 Ala665 (OR, 2.22; 95% CI, 1.28-3.84; P=.005) were associated with resistance.

• Authors: Chenglong Liu, Mary Carrington, Richard A Kaslow, Xiaojiang Gao, Charles R Rinaldo, Lisa P Jacobson, Joseph B Margolick, John Phair, Stephen J O'Brien, Roger Detels
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 187 Issue 9 Pg. 1404-10 (May 01 2003) ISSN: 0022-1899 [Print] United States
• PMID: 12717621 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• ATP Binding Cassette Transporter, Subfamily B, Member 2
• ATP-Binding Cassette Transporters
• Histocompatibility Antigens Class I
• TAP1 protein, human

Topics

• ATP Binding Cassette Transporter, Subfamily B, Member 2
• ATP-Binding Cassette Transporters (genetics)
• Adult
• Cohort Studies
• Genetic Predisposition to Disease
• Genotype
• HIV Infections (genetics, immunology)
• HIV Seropositivity (genetics, immunology)
• Histocompatibility Antigens Class I (genetics, immunology)
• Humans
• Male
• Multivariate Analysis
• Polymorphism, Genetic