Abstract | OBJECTIVES: METHODS: The presence of these three markers was determined in 196 patients with established RA, 239 non-RA controls with various rheumatic diseases (cross-sectional study) and in 27 patients with arthritis of less than 1 yr disease duration who were subsequently followed during about 8 yr (longitudinal study). At the time of follow-up, 21 of these 27 patients had RA. They were further evaluated and several clinical variables were recorded. RESULTS: The specificity was significantly increased (from 82-90% to 98% in the cross-sectional study) when the combination of anti-CCP antibodies with IgA RF or the combination of the three serological markers was used. An association was observed between the presence of the three autoantibodies and clinical signs of disease severity (functional disability, presence of erosions and absence of clinical remission). CONCLUSIONS: The presence either of anti-CCP antibodies and IgA RF or of the three markers appears to be useful in the diagnosis of RA. Their association with clinical signs of disease severity at the time of patient inclusion suggests their potential usefulness as markers for prognosis.
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Authors | S Bas, S Genevay, O Meyer, C Gabay |
Journal | Rheumatology (Oxford, England)
(Rheumatology (Oxford))
Vol. 42
Issue 5
Pg. 677-80
(May 2003)
ISSN: 1462-0324 [Print] England |
PMID | 12709545
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- Biomarkers
- Immunoglobulin A
- Immunoglobulin M
- Peptides, Cyclic
- Citrulline
- Rheumatoid Factor
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Arthritis, Rheumatoid
(diagnosis)
- Autoantibodies
(blood)
- Biomarkers
(blood)
- Citrulline
(immunology)
- Cross-Sectional Studies
- Diagnosis, Differential
- Female
- Humans
- Immunoglobulin A
(blood)
- Immunoglobulin M
(blood)
- Longitudinal Studies
- Male
- Middle Aged
- Peptides, Cyclic
(immunology)
- Prognosis
- Rheumatic Diseases
(diagnosis)
- Rheumatoid Factor
(blood)
- Sensitivity and Specificity
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