Role of the brain heme oxygenase-carbon monoxide pathway in stress fever in rats.

Abstract

This study was aimed at testing the hypothesis that the brain heme oxygenase (HO)-carbon monoxide (CO) pathway plays a role in stress fever. To this end, the effect of the HO inhibitor, zinc deuteroporphyrin 2,4-bis glycol (ZnDPBG), on restraint-induced fever was tested. Intracerebroventricular ZnDPBG (200 nmol) did not affect the body core temperature of unrestrained rats, but markedly attenuated restraint-induced fever. However, at the same dose, intraperitoneal ZnDPBG did not affect the febrile response to restraint. Taken together, these results indicate that the brain HO-CO pathway plays a major role in the genesis of stress fever in rats.

• Authors: Alexandre A Steiner, Gustavo Reste, Luiz G S Branco
• Journal: Neuroscience letters (Neurosci Lett) Vol. 341 Issue 3 Pg. 193-6 (May 08 2003) ISSN: 0304-3940 [Print] Ireland
• PMID: 12697281 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Enzyme Inhibitors
• Carbon Monoxide
• Heme Oxygenase (Decyclizing)

Topics

• Animals
• Brain (drug effects, enzymology)
• Carbon Monoxide (physiology)
• Enzyme Inhibitors (pharmacology)
• Fever (enzymology)
• Heme Oxygenase (Decyclizing) (antagonists & inhibitors, physiology)
• Male
• Rats
• Rats, Wistar
• Signal Transduction (drug effects, physiology)
• Stress, Physiological (enzymology)