Abstract | BACKGROUND: METHODS: RESULTS: Patients with Crohn's colitis or ulcerative colitis had less saturated bile (mean cholesterol saturation index, 0.9) and longer nucleation times (median, 21 days) than those with ileal Crohn's disease (1.5; 14 days) or those who had undergone colectomy (1.6; 5 days). In patients with ileal Crohn's disease, the mean biliary bilirubin concentration was two- to three-fold higher than that in the other groups, and was associated with a decrease in the percentage of biliary deoxycholate and an increase in the percentage of ursodeoxycholate, compared with disease controls, but phosphatidylcholine species were similar. CONCLUSIONS:
|
Authors | S P Pereira, I M Bain, D Kumar, R H Dowling |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 17
Issue 7
Pg. 923-33
(Apr 01 2003)
ISSN: 0269-2813 [Print] England |
PMID | 12656695
(Publication Type: Journal Article)
|
Chemical References |
- Bile Acids and Salts
- Phosphatidylcholines
- Cholesterol
- Bilirubin
|
Topics |
- Adult
- Aged
- Bile
(chemistry)
- Bile Acids and Salts
(analysis)
- Bilirubin
(analysis)
- Cholesterol
(analysis)
- Colectomy
- Crohn Disease
(metabolism, surgery)
- Crystallization
- Female
- Humans
- Male
- Middle Aged
- Phosphatidylcholines
(analysis)
|