Anti-protein Z antibodies in women with pathologic pregnancies.

Abstract

Protein Z deficiencies have recently been described in women with unexplained early fetal loss. Using a new, specifically elaborated, commercially available enzyme-linked immunosorbent assay (ELISA), we performed a case-control study on anti-protein Z immunoglobulin G (IgG) and IgM antibodies in 191 nonthrombotic, nonthrombophilic women with consecutive pathologic pregnancies. Levels of anti-protein Z antibodies were categorized in 3 strata (percentiles 1 through 74, 75 through 97, 98 through 100 among controls). The 2 upper levels of IgG and IgM anti-protein Z antibodies were associated with the risk of unexplained recurrent embryo loss or fetal death independently from habitual antiphospholipid/anticofactor antibodies, and a dose-effect relationship between antibody levels and the clinical risks was evidenced. In women, enhanced immune-complex formation with protein Z may play a role in unexplained embryo losses and, from the 10th week of gestation, may favor hypercoagulability in the maternal placenta side.

• Authors: Jean-Christophe Gris, Cécile Amadio, Eric Mercier, Géraldine Lavigne-Lissalde, Hervé Déchaud, Médéric Hoffet, Isabelle Quéré, Jean Amiral, Michel Dauzat, Pierre Marès
• Journal: Blood (Blood) Vol. 101 Issue 12 Pg. 4850-2 (Jun 15 2003) ISSN: 0006-4971 [Print] United States
• PMID: 12623836 (Publication Type: Journal Article)

Chemical References

• Antibodies, Anticardiolipin
• Antibodies, Antiphospholipid
• Autoantibodies
• Blood Proteins
• Glycoproteins
• Immunoglobulin G
• Immunoglobulin M
• beta 2-Glycoprotein I
• plasma protein Z

Topics

• Abortion, Spontaneous (immunology)
• Antibodies, Anticardiolipin (blood)
• Antibodies, Antiphospholipid (blood)
• Autoantibodies (blood)
• Blood Proteins (analysis, deficiency, immunology)
• Case-Control Studies
• Female
• Fetal Death (immunology)
• Gestational Age
• Glycoproteins (immunology)
• Humans
• Immunoglobulin G (blood)
• Immunoglobulin M (blood)
• Logistic Models
• Pre-Eclampsia (immunology)
• Pregnancy
• beta 2-Glycoprotein I