Abstract | OBJECTIVE: METHODS AND RESULTS: CONCLUSION: In experimental and human heart failure, both NF-kappaB and AP-1 are chronically activated in cardiac myocytes. These findings suggest an important involvement of NF-kappaB and AP-1 in the cardiac remodeling process.
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Authors | Stefan Frantz, Daniela Fraccarollo, Helga Wagner, Thomas M Behr, Philip Jung, Christiane E Angermann, Georg Ertl, Johann Bauersachs |
Journal | Cardiovascular research
(Cardiovasc Res)
Vol. 57
Issue 3
Pg. 749-56
(Mar 2003)
ISSN: 0008-6363 [Print] England |
PMID | 12618236
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin Receptor Antagonists
- Angiotensin-Converting Enzyme Inhibitors
- Biphenyl Compounds
- Indoles
- Interleukin-1
- NF-kappa B
- Tetrazoles
- Transcription Factor AP-1
- Tumor Necrosis Factor-alpha
- trandolapril
- Irbesartan
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Topics |
- Adult
- Angiotensin Receptor Antagonists
- Angiotensin-Converting Enzyme Inhibitors
(pharmacology)
- Animals
- Biphenyl Compounds
(pharmacology)
- Blotting, Western
- Enzyme-Linked Immunosorbent Assay
- Heart Failure
(metabolism)
- Humans
- Indoles
(pharmacology)
- Interleukin-1
(metabolism)
- Irbesartan
- Male
- Myocardial Infarction
(metabolism)
- NF-kappa B
(metabolism)
- Rats
- Rats, Wistar
- Tetrazoles
(pharmacology)
- Transcription Factor AP-1
(metabolism)
- Tumor Necrosis Factor-alpha
(metabolism)
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