Abstract | RATIONALE: OBJECTIVE: To investigate a dose-response relationship for paroxetine administration, and to determine whether a lower dose of paroxetine is sufficient to increase plasma ACTH and cortisol. METHODS: Twenty subjects were tested on three occasions in a double-blind, cross-over design receiving: (a) placebo, (b) paroxetine 20 mg and (c) paroxetine 40 mg administered orally at 8.00 a.m. In addition, five of the 20 subjects received paroxetine 20 mg plus cyproheptadine (a 5-HT(2) receptor antagonist) 4 mg and four subjects were given paroxetine 40 mg plus cyproheptadine 4 mg in an open manner. Plasma ACTH and cortisol levels were measured prior to administration and every hour for 6 h thereafter. RESULTS: CONCLUSIONS: Low-dose (20 mg) paroxetine has greater potential utility than larger doses as a neuroendocrine challenge test. The endocrine responses to paroxetine are probably mediated at least partially by 5-HT(2A/2C) receptors.
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Authors | H Kojima, T Terao, M Iwakawa, A Soya, N Inoue, Y Shiraishi, Y Son, S Soeda, N Ueda, R Yoshimura, J Nakamura |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 167
Issue 1
Pg. 97-102
(Apr 2003)
ISSN: 0033-3158 [Print] Germany |
PMID | 12601506
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptor, Serotonin, 5-HT2A
- Receptor, Serotonin, 5-HT2C
- Receptors, Serotonin
- Serotonin Antagonists
- Serotonin Uptake Inhibitors
- Cyproheptadine
- Paroxetine
- Adrenocorticotropic Hormone
- Hydrocortisone
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Topics |
- Adrenocorticotropic Hormone
(blood)
- Adult
- Cross-Over Studies
- Cyproheptadine
(pharmacology)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Female
- Humans
- Hydrocortisone
(blood)
- Male
- Middle Aged
- Paroxetine
(administration & dosage)
- Receptor, Serotonin, 5-HT2A
- Receptor, Serotonin, 5-HT2C
- Receptors, Serotonin
(drug effects)
- Serotonin Antagonists
(pharmacology)
- Selective Serotonin Reuptake Inhibitors
(administration & dosage)
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