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Paroxetine (Paxil)

A serotonin uptake inhibitor that is effective in the treatment of depression.
Also Known As:
Paxil; Seroxat; Aropax; Paroxetine Hydrochloride; BRL-29060; FG-7051; Paroxetine Acetate; Paroxetine Hydrochloride Anhydrous; Paroxetine Hydrochloride Hemihydrate; Paroxetine Hydrochloride, Hemihydrate; Paroxetine Maleate; Paroxetine, cis-(+)-Isomer; Paroxetine, cis-(-)-Isomer; Paroxetine, trans-(+)-Isomer; BRL 29060; BRL29060; FG 7051; FG7051; Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-, (3S-trans)-
Networked: 1858 relevant articles (292 outcomes, 428 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Yasui-Furukori, Norio: 17 articles (01/2018 - 04/2011)
2. Nakagami, Taku: 12 articles (01/2018 - 04/2011)
3. Kaneko, Sunao: 12 articles (05/2016 - 04/2011)
4. Tsuchimine, Shoko: 11 articles (01/2018 - 04/2011)
5. Pae, Chi-Un: 11 articles (08/2009 - 03/2003)
6. Pollock, Bruce G: 11 articles (01/2009 - 01/2002)
7. Stein, Dan J: 10 articles (10/2022 - 02/2002)
8. Kaneda, Ayako: 10 articles (01/2018 - 12/2011)
9. Tomita, Tetsu: 10 articles (01/2018 - 04/2011)
10. Stein, Murray B: 10 articles (01/2016 - 01/2002)

Related Diseases

1. Panic Disorder (Panic Attack)
2. Social Phobia
3. Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder)
01/01/2012 - "Patients treated with prolonged exposure plus paroxetine experienced significantly greater improvement in PTSD symptoms (incidence rate ratio=0.50, 95% CI=0.30-0.85) and remission status (odds ratio=12.6, 95% CI=1.23-129) during 10 weeks of combined treatment than patients treated with prolonged exposure plus placebo. "
11/01/2001 - "At week 12, compared with the placebo group (N = 156), the paroxetine group (N = 151) showed significantly greater reduction of PTSD symptoms on both of the primary and all of the secondary outcome measures. "
09/01/2015 - "In this, largest to date study comparing PE, paroxetine and combination treatment in PTSD PE was more effective than Ph in achieving remission of PTSD. "
03/01/2008 - "Counter to our hypothesis, however, we found no additive benefit of augmentation of continued PE with paroxetine CR compared to pill placebo for the 23 randomly assigned patients, with relatively minimal further gains overall in Phase II. Although replication with larger samples is needed before definitive conclusions can be drawn, our data do not support the addition of paroxetine CR compared with placebo to continued PE for individuals with PTSD who remain symptomatic after initial PE, suggesting that the development of novel treatment approaches for PTSD refractory to PE is needed. "
02/01/1998 - "The authors hypothesized that paroxetine might be effective in PTSD, based on findings of its particular efficacy for anxiety and agitation in studies of depressed patients. "
4. Anxiety Disorders (Anxiety Disorder)
5. Major Depressive Disorder (Major Depressive Disorders)

Related Drugs and Biologics

1. Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)
2. Venlafaxine Hydrochloride (Effexor)
3. Antidepressive Agents (Antidepressants)
4. Sertraline (Zoloft)
5. Fluoxetine (Prozac)
6. Escitalopram
7. Serotonin (5 Hydroxytryptamine)
8. Fluvoxamine (Luvox)
9. Citalopram
10. Clomipramine (Anafranil)

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Aftercare (After-Treatment)
4. Secondary Prevention
5. Duration of Therapy