Anti-tumor promoting effect of glycosides from Prunus persica seeds.

Abstract

Four minor components, along with the major cyanogenic glycosides, amygdalin and prunasin, were isolated from Prunus persica seeds (Persicae Semen; Tounin), and characterized as mandelic acid glycosides (beta-gentiobioside and beta-D-glucoside) and benzyl alcohol glycosides (beta-gentiobioside and beta-D-glucoside). The anti-tumor promoting activity of these compounds was examined in both in vitro and in vivo assays. All of the compounds significantly inhibited the Epstein-Barr virus early antigen activation induced by tumor promoter. In addition, they produced a delay of two-stage carcinogenesis on mouse skin that was comparable in potency to (-)-epigallocatechin gallate from green tea. Structure-activity relationships indicated that a substituent at the benzylic position with glycosidic linkage affected the in vitro and in vivo activities with an order of enhancing potency, CN<COOH<H.

• Authors: Toshiyuki Fukuda, Hideyuki Ito, Teruo Mukainaka, Harukuni Tokuda, Hoyoku Nishino, Takashi Yoshida
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 26 Issue 2 Pg. 271-3 (Feb 2003) ISSN: 0918-6158 [Print] Japan
• PMID: 12576693 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens, Viral
• Antineoplastic Agents
• Carcinogens
• Epstein-Barr virus early antigen
• Glycosides
• Plant Extracts

Topics

• Animals
• Antigens, Viral (metabolism)
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology, therapeutic use)
• Carcinogens (antagonists & inhibitors, metabolism)
• Female
• Glycosides (chemistry, isolation & purification, pharmacology, therapeutic use)
• Humans
• Mice
• Mice, Inbred ICR
• Plant Extracts (chemistry, isolation & purification, pharmacology, therapeutic use)
• Prunus
• Seeds
• Skin Neoplasms (drug therapy, metabolism)