Renal cell carcinoma with intratumoral calcium oxalate crystal deposition in patients with acquired cystic disease of the kidney.

Abstract

We describe 2 cases of renal cell carcinoma arising in acquired cystic disease of the kidney (ACDK) in patients with end-stage renal disease undergoing hemodialysis for more than 5 years and provide a brief review of the complications of ACDK. In both cases, abundant calcium oxalate crystals were observed within the tumors. Histologically, one of the tumors was a conventional (clear cell) renal cell carcinoma. The other tumor was a bilateral papillary renal cell carcinoma. Both tumors were high-grade carcinomas with extensive oncocytic (acidophilic) features. Also noted within the kidneys were cysts with atypical papillary hyperplasia. The clinicopathologic findings along with review of the literature suggest a relationship between tumor growth and calcium oxalate crystal deposition in patients undergoing hemodialysis with ACDK.

• Authors: Nathalie C Rioux-Leclercq, Jonathan I Epstein
• Journal: Archives of pathology & laboratory medicine (Arch Pathol Lab Med) Vol. 127 Issue 2 Pg. E89-92 (Feb 2003) ISSN: 1543-2165 [Electronic] United States
• PMID: 12562261 (Publication Type: Case Reports, Journal Article)

Chemical References

• Calcium Oxalate

Topics

• Adenocarcinoma, Clear Cell (diagnosis, metabolism)
• Adult
• Calcium Oxalate (metabolism)
• Carcinoma, Papillary (diagnosis, metabolism)
• Carcinoma, Renal Cell (diagnosis, metabolism)
• Crystallization
• Female
• Humans
• Kidney Diseases, Cystic (diagnosis)
• Kidney Failure, Chronic (therapy)
• Kidney Neoplasms (diagnosis, metabolism)
• Male
• Middle Aged
• Renal Dialysis