Abstract | OBJECTIVE: STUDY DESIGN: Parental consent was obtained prior to mechanical ventilation. Infants less than 1000 g without significant congenital anomalies were eligible for study entry. Infants were randomized, prior to the onset of mechanical ventilation, to receive either synchronized intermittent mandatory ventilation (SIMV) or high-frequency flow interruption. Both ventilator methods were obtained using the Infant Star Ventilator (Mallinckrodt, St. Louis, MO). Data were collected prospectively on all study entrants and analyzed using SigmaStat Software. RESULTS: Forty-six infants, from two centers, were enrolled in this study. There was no significant difference in the ventilator days or BPD, defined as oxygen requirement at 36 weeks postmenstrual age, between the high-frequency ventilation and SIMV groups.
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Authors | Alissa P Craft, V Bhandari, N N Finer |
Journal | Journal of perinatology : official journal of the California Perinatal Association
(J Perinatol)
Vol. 23
Issue 1
Pg. 14-9
(Jan 2003)
ISSN: 0743-8346 [Print] United States |
PMID | 12556921
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Topics |
- Bronchopulmonary Dysplasia
(prevention & control)
- Female
- High-Frequency Ventilation
- Humans
- Infant, Newborn
- Infant, Very Low Birth Weight
- Intermittent Positive-Pressure Ventilation
- Male
- Prospective Studies
- Respiratory Distress Syndrome, Newborn
(therapy)
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