GABA(A) receptor function and pharmacology in epilepsy and status epilepticus.

Abstract

GABA(A) (gamma-n-aminobutyric acid) receptor dysfunction has long been implicated in the development of epilepsy and status epilepticus. Recent advances have been made in understanding the cellular, pharmacological and genetic involvement of GABA(A) receptors in seizure disorders. In particular, genetic mutations found in GABA(A) receptor subunits strongly implicate the GABA(A) receptor in idiopathic generalised epilepsies.

• Authors: Dorothy M Jones-Davis, Robert L Macdonald
• Journal: Current opinion in pharmacology (Curr Opin Pharmacol) Vol. 3 Issue 1 Pg. 12-8 (Feb 2003) ISSN: 1471-4892 [Print] England
• PMID: 12550736 (Publication Type: Journal Article, Review)

Chemical References

• Anticonvulsants
• GABA-A Receptor Agonists
• GABA-A Receptor Antagonists
• Receptors, GABA-A

Topics

• Animals
• Anticonvulsants (pharmacology, therapeutic use)
• Epilepsy (drug therapy, metabolism)
• GABA-A Receptor Agonists
• GABA-A Receptor Antagonists
• Humans
• Receptors, GABA-A (chemistry, metabolism)
• Status Epilepticus (drug therapy, metabolism)