Abstract | BACKGROUND: Recently, a rapid-release 100-mg 13C-urea tablet with citrate supplement (Diabact UBT) showed excellent performance in a European population. AIM: To investigate the accuracy of a 50-mg tablet-based 13C-urea breath test protocol. METHODS: : Consecutive dyspeptic patients referred for upper endoscopy were recruited. 13C-Urea breath test was performed using a 50-mg 13C-urea tablet (Diabact UBT) and compared with the gold standard (rapid urease test and histology). Baseline, 10-min, 20-min and 30-min breath samples were collected in all cases. The cut-off values at each measurement interval were determined by three standard deviations above the mean excess delta 13CO2 excretion of Helicobacter pylori-negative patients. RESULTS: Two hundred patients (150 before therapy and 50 after therapy) were available for analysis, with a mean age of 48.4 years, and 99 patients (50%) were H. pylori positive. The sensitivity and specificity of the 50-mg tablet-based 13C-urea breath test at 10 min, 20 min and 30 min were 100% and 98%, 100% and 100%, and 100% and 98%, respectively. CONCLUSION: A 20-min, 50-mg tablet-based 13C-urea breath test (Diabact UBT) protocol is highly accurate for the diagnosis of H. pylori infection.
|
Authors | W M Wong, S K Lam, K C Lai, K M Chu, H H X Xia, K W Wong, K L Cheung, S K Lin, B C Y Wong |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 17
Issue 2
Pg. 253-7
(Jan 2003)
ISSN: 0269-2813 [Print] England |
PMID | 12534410
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Carbon Isotopes
- Drug Combinations
- Tablets
- Citric Acid
- Urea
|
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Breath Tests
- Carbon Isotopes
- Citric Acid
(administration & dosage)
- Drug Combinations
- Dyspepsia
(microbiology)
- Female
- Helicobacter Infections
(diagnosis)
- Helicobacter pylori
- Humans
- Male
- Middle Aged
- Sensitivity and Specificity
- Tablets
- Urea
(administration & dosage, analysis)
|