[Experimental research on inhibitory effect of alcohol extracts from Loranthus yadoriki Sieb. on coxsackie B3 virus].

Abstract

OBJECTIVE:

To investigate the antiviral effect of two components (B and C) in the alcohol extracts from Loranthus yadoriki Sieb for development of new antiviral drugs for coxsackie B3 virus(CVB3).

METHOD:

Using ribavirin as positive control, the plaque reduction assay was adopted for pharmadynamic detection.

RESULTS:

In the HEp-2 cell system, with respect to direct virucidal activity and the inhibition on CVB3 infection and multiplication, ED50s of component B were 2.32 micrograms.ml-1, 0.24 microgram.ml-1 and 1.91 micrograms.ml-1, respectively and those of component C, 1.44 micrograms.ml-1, 2.06 micrograms.ml-1 and 3.70 micrograms.ml-1 respectively. For the inhibition on multiplication of CVB3, ED50 of ribavirin was 7.55 micrograms.ml-1.

CONCLUSION:

Treatment indexes (TI) of the direct virucidal activity and inhibitory effects of component B on CVB3 infection and multiplication 22.6, 219 and 27.5 respectively; component C, 115, 165 and 21.6; inhibition of ribavirin on CVB3 is 38, which is comparable to those of components B and C. It is thus suggested that the anti-CVB3 action of components B and C in the alcohol extracts from Loranthus yadoriki Sieb deserves to be exploited.

• Authors: Z J Wang, Z Q Yang, T N Huang, L Wen, Y W Liu
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 25 Issue 11 Pg. 685-7 (Nov 2000) ISSN: 1001-5302 [Print] China
• PMID: 12525075 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antiviral Agents
• Drugs, Chinese Herbal

Topics

• Antiviral Agents (pharmacology)
• Drugs, Chinese Herbal (isolation & purification, pharmacology)
• Enterovirus B, Human (drug effects)
• Loranthaceae (chemistry)
• Plants, Medicinal (chemistry)