Abstract | BACKGROUND/AIMS: METHODS: The precore/core gene sequence was determined by polymerase chain reaction (PCR) and direct sequencing of PCR product in serum samples obtained before interferon treatment from 10 responders and 10 non-responders to interferon therapy. In addition, precore/core gene sequence was determined in serum samples obtained before interferon treatment and after recurrence from 10 patients who showed recurrence of HBeAg and HBV DNA after initial response to interferon therapy. RESULTS: In samples from 10 responders, there were 7 missense mutations and 71 silent mutations. However, there were 43 missense mutations and 109 silent mutations in samples from 10 non-responders. In samples obtained before interferon treatment from the 10 patients who showed recurrence after initial response, 8 missense mutations and 74 silents mutations were found. The nucleotide sequences from the samples obtained after the recurrence showed 6 silent nucleotide substitutions compared with the sequences from the samples obtained before interferon treatment. CONCLUSIONS:
|
Authors | Byung Chul Yoo, Hyung Joon Kim, Jae Hyuk Do, Sill Moo Park |
Journal | Taehan Kan Hakhoe chi = The Korean journal of hepatology
(Taehan Kan Hakhoe Chi)
Vol. 8
Issue 4
Pg. 381-8
(Dec 2002)
ISSN: 1226-0479 [Print] Korea (South) |
PMID | 12506242
(Publication Type: English Abstract, Journal Article)
|
Chemical References |
- Antiviral Agents
- DNA, Viral
- Interferon-alpha
- Viral Core Proteins
|
Topics |
- Adolescent
- Adult
- Antiviral Agents
(therapeutic use)
- DNA, Viral
(genetics)
- Female
- Hepatitis B virus
(genetics)
- Hepatitis B, Chronic
(drug therapy, virology)
- Humans
- Interferon-alpha
(therapeutic use)
- Male
- Mutation
- Viral Core Proteins
(genetics)
|