Abstract | PURPOSE: To evaluate the impact of selenium chemoprevention (200 microg/day) on hospitalizations in HIV-positive individuals. METHOD: Data were obtained from 186 HIV+ men and women participating in a randomized, double-blind, placebo-controlled selenium clinical trial (1998-2000). Supplements were dispensed monthly, and clinical evaluations were conducted every 6 months. Inpatient hospitalizations, hospitalization costs, and rates of hospitalization were determined 2 years before and during the trial. RESULTS: At enrollment, no significant differences in CD4 cell counts or viral burden were observed between the two study arms. Fewer placebo-treated participants were using antiretrovirals (p <.05). The total number of hospitalizations declined from 157 before the trial to 103 during the 2 year study. A marked decrease in total admission rates (RR = 0.38; p =.002) and percent of hospitalizations due to infection/100 patients for those receiving selenium was observed (p =.01). As a result, the cost for hospitalization decreased 58% in the selenium group, compared to a 30% decrease in the placebo group (p =.001). In the final analyses, selenium therapy continued to be a significant independent factor associated with lower risk of hospitalization (p =.001). CONCLUSION:
Selenium supplementation appears to be a beneficial adjuvant treatment to decrease hospitalizations as well as the cost of caring for HIV-1-infected patients.
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Authors | Ximena Burbano, Maria Jose Miguez-Burbano, Kathryn McCollister, Guoyan Zhang, Allan Rodriguez, Phillip Ruiz, Robert Lecusay, Gail Shor-Posner |
Journal | HIV clinical trials
(HIV Clin Trials)
2002 Nov-Dec
Vol. 3
Issue 6
Pg. 483-91
ISSN: 1528-4336 [Print] England |
PMID | 12501132
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Adult
- Antiretroviral Therapy, Highly Active
- CD4 Lymphocyte Count
- Chemotherapy, Adjuvant
- Dietary Supplements
- Double-Blind Method
- Female
- Florida
- HIV Infections
(drug therapy, economics, prevention & control)
- Hospital Costs
- Hospitalization
(economics, statistics & numerical data)
- Humans
- Male
- Middle Aged
- Selenium
(administration & dosage)
- Treatment Outcome
- Viral Load
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